Intelectin1 ameliorates macrophage activation via inhibiting the nuclear factor kappa B pathway.
Kobayashi H, Uchimura K, Ishii T, Takahashi K, Mori K, Tsuchiya K, Furuya F.
Endocr J. 2021 doi: 10.1507/endocrj.EJ21-0438.
NKX2-1 re-expression induces cell death through apoptosis and necrosis in dedifferentiated thyroid carcinoma cells.
Ito Y, Furuya F, Taki K, Suzuki H, Shimura H.
PLoS One. 2021;16(11):e0259558.
Hyperthyroidism exacerbates ischemic reperfusion injury in the kidney.
Yamaguchi Y, Uchimura K, Takahashi K, Ishii T, Hanai S, Furuya F.
Endocr J. 2021 doi: 10.1507/endocrj.EJ21-0395.
Position paper from the Japan Thyroid Association task force on the management of low-risk papillary thyroid microcarcinoma (T1aN0M0) in adults.
Horiguchi K※, Yoshida Y, Iwaku K, Emoto N, Kasahara T, Sato J, Shimura H, Shindo H, Suzuki S, Nagano H, Furuya F, Makita N, Matsumoto F, Manaka K, Mitsutake N, Miyakawa M, Yokoya S, Sugitani I.
Endocr J. 2021; 68:763-780.
Membranous Nephropathy with Proteinase 3-ANCA-associated Vasculitis Successfully Treated with Rituximab.
Yoshida S, Hanai S, Nakagomi D, Kobayashi K, Takahashi K, Furuya F.
Intern Med. 2021; 60:145-150.
Development of the Diabetic Kidney Disease Mouse Model Culturing Embryos in α- Minimum Essential Medium In Vitro, and Feeding Barley Diet Attenuated the Pathology.
Ishiyama S, Kimura M, Nakagawa T, Fujimoto Y, Uchimura K, Kishigami S, Mochizuki K.
Front Endocrinol (Lausanne). 2021; 12:746838.
Liver-specific overexpression of prostasin attenuates high-fat diet-induced metabolic dysregulation in mice.
Sekine T, Takizawa S, Uchimura K, Miyazaki A, Tsuchiya K.
Int. J. Mol. Sci. 2021; 22(15), 8314.
A serine protease inhibitor camostat mesilate prevents podocyte apoptosis and attenuates podocyte injury in metabolic syndrome model rats.
Mizumoto T, Kakizoe Y, Nakagawa T, Iwata Y, Miyasato Y, Uchimura K, Adachi M,
Deng Q, Hayata M, Morinaga J, Miyoshi T, Izumi Y, Kuwabara T, Sakai Y, Tomita K,
Kitamura K, Mukoyama M.
J Pharmacol Sci. 2021;146(4):192-199.
Improved Human Pluripotent Stem Cell-Derived Kidney Organoids for Modeling Collecting Duct Biology and Tubular Injury
Kohei Uchimura, Haojia Wu, Benjamin D Humphreys
第63回日本腎臓学会学術総会
Membranous nephropathy with proteinase 3-ANCA-associated vasculitis successfully treated with rituximab
Yoshida S, Hanai S, Nakagomi D, Kobayashi K, Takahashi K, Furuya F.
Intern Med. 2021 Jan 1;60(1):145-150.
Hayashida R, Tsuchiya K, Nakamura S, Harima N, Ichijo M, Furuya F, Kitamura K. Acute Kidney Injury with Hemolysis after Glycerin Enema-induced Rectal Injury in a Patient with Type 2 Diabetes.
Intern Med. 2020;59(13):1659-1663.
Cell profiling of mouse acute kidney injury reveals conserved cellular responses to injury.
Kirita Y, Wu H, Uchimura K, Wilson PC, Humphreys BD
Proc Natl Acad Sci U S A. 2020 Jul 7;117(27):15874-15883
Human Pluripotent Stem Cell-Derived Kidney Organoids with Improved Collecting Duct Maturation and Injury Modeling
Uchimura K, Wu H, Yoshimura Y, Humphreys BD.
Cell Rep. 2020 Dec 15;33(11):108514. doi: 10.1016
Kohei Uchimura, Haojia Wu, Benjamin D. Humphreys
Improved Human Pluripotent Stem Cell-Derived Kidney Organoids for Modeling Collecting Duct Biology and Tubular Injury
ASN Kidney Week 2019, FR-OR049 Washington D.C., 2019 November
Association between the Cardio-Ankle Vascular Index and Diabetes Mellitus-Related Peripheral Arterial Disease in Chronic Hemodialysis Patients.
Furuya F, Motosugi A, Haraguchi K, Hanai S, Ishii T, Yamaguchi Y, Kitamura K.
Blood Purif. 2019;47 .2:25-30
The single-cell transcriptomic landscape of early human diabetic nephropathy.
Wilson PC, Wu H, Kirita Y, Uchimura K, Ledru N, Rennke HG, Welling PA, Waikar SS, Humphreys BD.
Proc Natl Acad Sci U S A. 2019 Sep 24;116(39):19619-19625.
Circulating angiopoietin-like protein 2 levels and mortality risk in patients receiving maintenance hemodialysis: a prospective cohort study.
Morinaga J, Kakuma T, Fukami Hayata M, Uchimura K, Mizumoto T, Kakizoe Y, Miyoshi T, Shiraishi N, Adachi M, Izumi Y, Kuwabara T, Okadome Y, Sato M, Horiguchi H, Sugizaki T, Kadomatsu T, Miyata K, Tajiri S, Tajiri T, Tomita K, Kitamura K, Oike Y, Mukoyama M.
Nephrol Dial Transplant. 2019 Dec 16.
Graft immaturity and safety concerns in transplanted human kidney organoids.
Nam SA, Seo E, Kim JW, Kim HW, Kim HL, Kim K, Kim TM, Ju JH, Gomez IG, Uchimura K, Humphreys BD, Yang CW, Lee JY, Kim J, Cho DW, Freedman BS, Kim YK.
Exp Mol Med. 2019 Nov 28;51(11):145
英文総説
Chronic Inflammation and Progression of Diabetic Kidney Disease.
Furuya F, Ishii T, Kitamura K.
Contrib Nephrol. 2019;198:33-39
受賞
古屋文彦： 第39回（平成31年度） 日本内分泌学会 研究奨励賞
助成金
石井俊史：日本学術振興会 科学研究助成事業 若手研究
高村武之：日本学術振興会 科学研究助成事業 若手研究
内村 幸平：iPSアカデミアジャパン
2018年
国内学会発表
Angiopoietin-like protein 2 regulates the progression of diabetic kidney disease
Ishii, T., Furuya, F., Kobayashi, H., Kitamura, K.
第91回内分泌学会学術総会 2018年4月 宮崎
Tonsillar expression of B-cell activating factors and glucose deficiet IgA1 correlates with disease activity of IgA nephropathy
Konishi, M., Furuya, F., Kitamura, K.
55 ERA-EDTA, May 2018, Copenhagen
Serum Fetuin-A levels associated with cardiovascular disease in hemodialysis patients with diabetes
Ohkoshi,K., Furuya, F., Kitamura,K.
55 ERA-EDTA, May 2018, Copenhagen
Serum IgA/C3 ratio may be a useful serologic marker to predict remission and disease progression in patients with adult onset IgA vasculitis
Takamura,T., Furuya, F., Kitamura,K.
55 ERA-EDTA, May 2018, Copenhagen
Angiopoietin-like protein 2 regulates the progression of diabetic kidney disease
Ishii, T., Furuya, F., Kitamura, K.
ASN Kidney Week, October 2018, San Diego
Brain Derived Neurotrophic Factor (BDNF) Inhibition Dramatically Reduces Off-Target Cells in Kidney Organoid
Kohei Uchimura, Haojia Wu, Erinn L Donnelly, Benjamin D. Humphreys
ASN Kidney Week 2018, TH-PO630, San Diego, 2018 November
Angiopoietin-Like Protein 2 Promotes the Progression of Diabetic Kidney Disease
Ishii, T., Furuya, F., Takahashi, K., Shikata, M., Takamura, T., Kobayashi, H., Miyazaki, A., Morinaga, J., Terada, K., Oike, Y., Kanda, E., Kitamura, K.
J Clin Endocrinol Metab. 2019 Jan 1;104(1):172-180.
Association between the cardio-Ankle Vascular Index and Diabetes Mellitus-related peripheral Arterial Disease in Chronic Hemodialysisi Patients
Furuya, F., Motosugi, A., Haraguchi, K., Hanai, S., Ishii, T., Yamaguchi, Y., Kitamura, K.
Blood Purification 2019 in press DOI: 10.1159/000496632
Essential points from Evidence-based Clinical Practice Guidelines for Chronic Kidney Disease 2018.
Okada, H., Kitamura, K., Furuya, F., Takahashi, K., Akiyama, D., et.al.
Clin Exp Nephrol. 2019 Jan;23(1):1-15. doi: 10.1007/s10157-018-1648-1.
Hepatocyte growth factor activator inhibitor-2 stabilizes Epcam and maintains epithelial organization in the mouse intestine.
Kawaguchi M, Yamamoto K, Takeda N, Fukushima T, Yamashita F, Sato K, Kitamura K, Hippo Y, Janetka JW, Kataoka H.
Commun Biol. 2019 Jan 4;2:11. doi: 10.1038/s42003-018-0255-8.
Benzbromarone Attenuates Oxidative Stress in Angiotensin II- and Salt-Induced Hypertensive Model Rats.
Muraya N, Kadowaki D, Miyamura S, Kitamura K, Uchimura K, Narita Y, Miyamoto Y, Chuang VTG, Taguchi K, Maruyama T, Otagiri M, Hirata S.
Oxid Med Cell Longev. 2018 Jun 5;2018:7635274. doi: 10.1155/2018/7635274.
Single-Cell Transcriptomics of a Human Kidney Allograft Biopsy Specimen Defines a Diverse Inflammatory Response.
Wu H, Malone AF, Kirita Y, Uchimura K, Ramakrishnan SM, Humphreys BD
J Am Soc Nephrol. 2018 Aug;29(8):2069-2080
Comparative Analysis and Refinement of Human PSC-Derived Kidney Organoid Differentiation with Single-Cell Transcriptomics.
Wu H, Uchimura K※, Donnelly EL, Kirita Y, Morris SA, Humphreys BD ※共同筆頭著者
Cell Stem Cell. 2018 Dec 6;23(6):869-881
英文総説
Chronic Inflammation and Progression of Diabetes Kidney Disease
Furuya, F., Ishii, T., Kitamura, K.
Nakanishi T, Kuragano T (eds): CKD-Associated Complications: Progress in the Last Half Century. Contrib Nephrol. Basel, Karger, 2019, vol 198, pp 34–40 (DOI: 10.1159/000496526)
受賞
石井 俊史: 第23回日本病態プロテアーゼ学会学術集会 Young Investigator‛s Award（YIA）2018年8月 山梨
Thyroid hormone represses the activation of NF-kB pathway and ameliorates kidney injury.
Takamura, T., Furuya, F., Oku, T., and Kitamura, K.
54th annual meeting of ERA-EDTA, June 2018, Madrid
Serum angiopoietin like2 and progression of diabetic nephropathy.
Konishi, M., Furuya, F., Oku, T., Takamura, T., and Kitamura, K.
54th annual meeting of ERA-EDTA, June 2018, Madrid
Risk factors of tuberculosis in the patients with hemodialysis.
Oku, T., Furuya, F., Kitamura, K., and Nishio, Y.
54th annual meeting of ERA-EDTA, June 2018, Madrid
Serum IgA/C3 ratio may be a useful serologic marker to predict remission and disease progression in patients with adult onset IgA vasculitis.
Takamura, T., Furuya, F., Jinguji, Y., and Kitamura, K.
American Society of Nephrology Kidney Week 2017, October 2017, New Orleans
Inappropriate expression of angiopoietin-like 2 promotes podocytes dysfunction by activating focal adhesion kinase in diabetic kidney disease.
Ishii, T., Furuya, F., Kobayashi, H., and Kitamura, K.
American Society of Nephrology Kidney Week 2017, October 2017, New Orleans
Omentin1 ameliorates hyperglycemia or hypoxia-Induced podocyte dysfunction by activating AMP-activating protein kinase.
Kobayashi, H., Furuya, F., Ishii, T., and Kitamura, K.
American Society of Nephrology Kidney Week 2017, October 2017, New Orleans
The role of serine proteases on glomerular injuries in salt-sensitive hypertension.
Iwata, Y., Kakizoe, Y., Nakagawa, T., Izumi, Y., Kuwabara, T., Adachi, M., Kitamura, K., and Mukoyama, M.
American Society of Nephrology Kidney Week 2017, October 2017, New Orleans
Serum IgA/C3 ratio may be a useful serologic marker to predict remission and disease progression in patients with adult onset IgA vasculitis.
Takamura, T., Furuya, F., Jinguji, Y., and Kitamura, K.
ISN Frontiers Meetings, February 2018, Tokyo
Two cases of Castleman’s disease accompanied with kidney dysfunction.
Takahashi, Y., Furuya, F., Akiyama, D., Hanai, S., Takahashi, K., and Kitamura, K.
ISN Frontiers Meetings, February 2018, Tokyo
Association of cardio-ankle vascular index with diabetes mellitus-related peripheral arterial disease in chronic hemodialysis patients.
Yamaguchi, Y., Furuya, F., and Kitamura, K.
ISN Frontiers Meetings, February 2018, Tokyo
Omentin1 ameliorates hypoxia-induced podocyte dysfunction by activating AMP-activating protein kinase.
Kobayashi, H., Furuya, F., and Kitamura, K.
ISN Frontiers Meetings, February 2018, Tokyo
Successful treatment of thrombotic microangiopathy (TMA) due to ANCA-associated vasculitis.
Konishi, M., Takamura, T., Takahashi, K., Akiyama, D., Furuya, F., and Kitamura, K.
ISN Frontiers Meetings, February 2018, Tokyo
Angiopoietin-like protein 2 regulates the progression of diabetic kidney disease.
Ishii, T., Furuya, F., Kobayashi, H., and Kitamura, K.
ISN Frontiers Meetings, February 2018, Tokyo
Hypokalemic myopathy induced by distal renal tubular acidosis associated with Sjögren’s syndrome.
Okoshi, K., Ajima, C., Yamaguchi, Y., Takeda, R., Hanai, S., Nakagomi, D., Furuya, F., and Kitamura, K.
ISN Frontiers Meetings, February 2018, Tokyo
Successful treatment of membranous nephropathy in a patient with mixed connective tissue disease by combination therapy of tacrolimus and intravenous cyclophosphamide.
Osano, K., Uchinuma, H., Okoshi, K., Hanai, S., Takahashi, K., Nakagomi, D., Akiyama, D., Fumihiko, F., and Kitamura, K.
ISN Frontiers Meetings, February 2018, Tokyo
A cases of nephritic syndrome complicated with alcoholic liver cirrhosis
Oku, T., Furuya, F., Shikata, M., Akiyama, D., Haneda, M., Nishio, Y., and Kitamura, K.
ISN Frontiers Meetings, February 2018, Tokyo
A case of acute kidney injury caused after mycoplasma pneumonia in renal amyloidosis.
Watanabe, M., Takahashi, K., Konishi, M., Takahashi, Y., Akiyama, D., Furuya, F., and Kitamura, K.
ISN Frontiers Meetings, February 2018, Tokyo
Doxycycline attenuates cisplatin-induced nephrotoxicity through pleiotropic effects.
Mizumoto, T., Kakizoe, Y., Nakagawa, T., Izumi, Y., Kuwabara, T., Adachi, M., Kitamura, K., and Mukoyama, M.
ISN Frontiers Meetings, February 2018, Tokyo
The role of serine proteases on glomerular injuries in salt-sensitive hypertension.
Iwata, Y., Kakizoe, Y., Nakagawa, T., Izumi, Y., Kuwabara, T., Adachi, M., Kitamura, K., and Mukoyama, M.
ISN Frontiers Meetings, February 2018, Tokyo
Zhang, X.M., Wang, H., Mine, S., Takemoto, M., Yokote, K., Kitamura, K., Kobayashi, Y., Machida, T., Kobayashi, E., Yoshida, Y., Matsutani, T., Iwadate, Y., Tomiyoshi, G., Nakamura, R., Shinmen, N., Kuroda, H., and Hiwasa, T.
Association of serum anti-prolylcarboxypeptidase antibody marker with atherosclerotic diseases accompanied by hypertension.
J. Mol. Biomark. Diagn., 8: 361, 2017
Sugimoto, K., Tomiyoshi, G., Mori, M., Kuwabara, S., Hirano, S., Sawai, S., Beppu, M., Muto, M., Uzawa, A., Kitamura, K., Takemoto, M., Hattori, A., Yamamoto, M., Kobayashi, K., Kawamura, H., Ishibashi, R., Yokote, K., Mine, S., Machida, T., Kobayashi, E., Yoshida, Y., Matsutani, T., Iwadate, Y., Kobayashi, Y., Nakamura, R., Shinmen, N., Kuroda, H., Wang, H., Zhang, X.M., and Hiwasa, T.
Identification of serum anti-GADD34 antibody as a common marker of diabetes mellitus and Parkinson disease.
J. Alzheimers. Dis. Parkinsonism., 7: 358, 2017
Hiwasa, T., Tomiyoshi, G., Nakamura, R., Shinmen, N., Kuroda, H., Kunimatsu, M., Mine, S., Machida, T., Sato, E., Takemoto, M., Hattori, A., Kobayashi, K., Kawamura, H., Ishibashi, R., Yokote, K., Kitamura, K., Ohno, M., Chen, P.M., Nishi, E., Ono, K., Kimura, T., Takizawa, H., Kashiwado, K., Kamitsukasa, I., Wada, T., Aotsuka, A., Sunami, K., Kobayashi, E., Yoshida, Y., Matsutani, T., Iwadate, Y., Mori, M., Uzawa, A., Muto, M., Sugimoto, K., Kuwabara, S., Iwata, Y., Kobayashi, Y., Terada, J., Matsumura, T., Sakao, S., Tatsumi, K., Ito, M., Shimada, H., Zhang, X.M., Kimura, R., Wang, H., Iwase, K., Ashino, H., Taira, A., Arita, E., Goto, K., Kudo, T., and Doi, H.
Serum SH3BP5-specific antibody level is a biomarker of atherosclerosis.
Immunome. Res., 13(2): 1-11, 2017
Thyroid hormons regulate glucose metabolism.
Harai, N., Furuya, F., and Kitamura, K.
Journal of the Japan thyroid association. 8(2): 123-134, 2017
助成金
内村 幸平：Advances in Research Conference Early Program Travel Support Travel Grant,
THYROID HORMONE RECEPTOR ON MACROPHAGES AMELIORATE IL1 RECEPTOR=ASSOCIATED KIDNEY FIBROSIS
Shikata, M., Furuya, F., Kitamura, K.
第53回 ERA-EDTA 2016年5月Austria
ASSOCIATION OF SERUM OMENTIN WITH A MARKER OF PROGRESSION OF DIABETIC NEPHROPATHY
Takeda-Koh, R., Furuya, F., Kobayashi, H., Kitamura, K.
第53回 ERA-EDTA 2016年5月Austria
SKIN AUTOFLUORESCENCE IS A PREDICTOR OF PROGRESSION OF DIABETIC COMPLICATIONS
Oku, T., Furuya, F., Haraguchi, K., Kitamura, K.
第53回ERA-EDTA 2016年5月Austria
EFFICACY OF FEBUXOSTAT IN TYPE 2 DIABETIC PATIENTS WITH KIDNEY IMPAIRMENT
Akiyama, D., Furuya, F., Wakasugi, M., Kitamura, K.
第53回 ERA-EDTA 2016年5月Austria
Thyroid Hormone Receptor on Macrophages Ameliorate Kidney Injury via Inhibition of Nuclear Factor-κB Activities
Ishii, T., Furuya, F., Kitamura, K., Ligand-Bound
American society of nephrology KIDNEY WEEK 2016 2016年11月CHICAGO
Two cases of adult onset IgA vasculitis with acute kidney injury and severe gastrointestinal manifestations:Successful treatment with factor XIII supplement
Takamura, T., Furuya, F., Kitamura, K.
American society of nephrology KIDNEY WEEK 2016 2016年11月CHICAGO
Omentin1 regulates podocyte function and albuminuria
Kobayashi, H., Furuya, F., Kitamura, K.
American society of nephrology KIDNEY WEEK 2016 2016年11月CHICAGO
Rabbit Monoclonal Antibody (RabMAb) Validation in Mouse and Human Kidney
Kohei Uchimura and Benjamin D. Humphreys
RBK (ReBuilding a Kidney) executive meeting, Chicago, 2016 November
The ligand-bound thyroid hormone receptor in macrophages ameliorates kidney injury via inhibition of nuclear factor-κB activities
Furuya, F., Ishii, T., Tamura, S., Takahashi, K., Kobayashi, H., Ichijo, M., Takizawa, S., Kaneshige, M., Suzuki-Inoue, K., Kitamura, K.
Sci Rep. Mar 8;7: 2017
An anti-deoxyhypusine synthase antibody as a marker of atherosclerosis-related cerebral infarction, myocardial infarction, diabetes mellitus, and chronic kidney disease.
Nakamura, R., Tomiyoshi, G., Shinmen, N., Kuroda, H., Kudo, T., Doi, H., Mine, S., Machida, T., Kamitsukasa, I., Wada, T., Aotsuka, A., Kobayashi, E., Yoshida, Y., Matsutan, T., Iwadate, Y., Mori, M., Uzawa, A., Muto, M., Sugimoto, K., Kuwabara, S., Takemoto, M., Hattori, A., Kobayashi, K., Awamura, H., Ishibashi, R., Yokote, K., Iwata, Y., Harada, J., Kobayashi, Y., Terada, J., Matsumura, T., Sakao, S., Tatsumi, K., Ohno, M., Chen, P. M., Nishi, E., Ono, K., Kimura, T., Kitamura, K., Takizawa, H., Kashiwado, K., Shimada, H., Ito, M., Goto, K., Zhang, X. M., Kimura, R., Wang, H., Taira, A., Arita, E., Shino, H., Iwase, K., and Hiwasa, T
SM Atheroscler J. 2017; 1(1):
Pharmacological and genetic reappraisals of protease and oxidative stress pathways in a mouse model of obstructive lung diseases.
Shuto, T., Kamei, S., Nohara, H., Fujikawa, H., Tasaki, Y., Sugahara, T., Ono, T., Matsumoto, C., Sakaguchi, Y., Maruta, K., Nakashima, R., Kawakami, T., Suico, M. A., Kondo, Y., Ishigami, A., Takeo, T., Tanaka, K.-I., Watanabe, H., Nakagata, N., Uchimura, K., Kitamura, K., Li, J. D., and Kai, H.
Sci. Rep. 6: 39305, 2016
A serine protease inhibitor attenuates aldosterone-induced kidney injury via the suppression of plasmin activity.
Kakizoe, Y., Miyasato, Y., Onoue, T., Nakagawa, T., Hayata, M., Uchimura, K., Morinaga, J., Adachi, M., Miyoshi, T., Sakai, Y., Tomita, K., Mukoyama, M., and Kitamura, K.
J. Pharmacol. Sci. 132: 145-153, 2016
Mild systemic thermal therapy ameliorates renal dysfunction in a rodent model of chronic kidney disease.
Iwashita, Y., Kuwabara, T., Hayata, M., Kakizoe, Y., Izumi, Y., Iiyama, J., Kitamura, K., and Mukoyama, M.
Am. J. Physiol. (Renal Physiol.) 310: F1206-1215, 2016
ESA Hyporesponsiveness Is Associated with Adverse Events in Maintenance Hemodialysis (MHD) Patients, But Not with Iron Storage.
Kuragano, T., Kitamura, K., Matsumura, O., Matsuda, A., Hara, T., Kiyomoto, H., Murata, T., Fujimoto, S., Hase, H., Joki, N., Fukatsu, A., Inoue, T., Itakura, Y., and Nakanishi, T.
PLoS One 11: e0147328, 2016
Combination therapy with renin-angiotensin-aldosterone system inhibitor telmisartan and serine protease inhibitor camostat mesilate provides further renoprotection in a rat chronic kidney disease model.
Narita, Y., Ueda, M., Uchimura, K., Kakizoe, Y., Miyasato, Y., Mizumoto, T., Morinaga, J., Hayata, M., Nakagawa, T., Adachi, M., Miyoshi, T., Sakai, Y., Kadowaki, D., Hirata, S., Mukoyama, M., and Kitamura, K.
J. Pharmacol. Sci. 130: 110-116, 2016
Angiopoietin-like protein 2 increases renal fibrosis by accelerating transforming growth factor-β signaling in chronic kidney disease.
Morinaga, J., Kadomatsu, T., Miyata, K., Endo, M., Terada, K., Tian, Z., Sugizaki, T., Tanigawa, H., Zhao, J., Zhu, S., Sato, M., Araki, K., Iyama, K., Tomita, K., Mukoyama, M., Tomita, K., Kitamura, K., and Oike, Y.
Kidney Int. 89: 327-341, 2016
Successful treatment of rapidly progressive Immunoglobulin A nephropathy with human immunodeficiency virus infection by steroid pulse therapy and tonsillectomy
Miyasato, Y., Miyoshi, T., Fujimoto, D., Adachi, M., Kitamura, K., and Mukoyama, M.
Nephrology 21: 159-160, 2016
受賞
石井 俊史：Kidney Summit 2016 奨励賞 2016年12月
助成金
内村 幸平：日本学術振興会 海外特別研究員
内村 幸平：ASN Campbell Fellows Travel Support Travel Grant
Serum omentin and progression of diabetic nephropathy
Oku, T., Furuya, F., Akiyama, D., Takahashi, K., Kobayashi, H., Kitamura, K.
American Society of Nephrology Kidney Week 2015, Nov 2015, California
Successful treatment of a case with septic shock and catastrophic antiphospholipid syndrome (CAPS) by plasma exchange therapy
Takamura, T., Furuya, F., Uchimura, K., Takahashi, K., Kitamura, K.
American Society of Nephrology Kidney Week 2015, Nov 2015, California
Decreased serum omentin is associated with risk of cardiorenal dysfunction in diabetes patients
Ishii, T., Furuya, F., Kobayashi, H., Kitamura, K.
European Renal Association–European Dialysis and Transplant Association 52nd Congressm, May 2015, London
ESA Hyporesponsiveness Is Associated with Adverse Events in Maintenance Hemodialysis (MHD) Patients, But Not with Iron Storage.
Kuragano, T., Kitamura, K., Matsumura, O., Matsuda, A., Hara, T., Kiyomoto, H., Murata, T., Fujimoto, S., Hase, H., Joki, N., Fukatsu, A., Inoue, T., Itakura, Y., and Nakanishi, T.
PLoS One, 11: e0147328, 2016
Combination therapy with renin-angiotensin-aldosterone system inhibitor telmisartan and serine protease inhibitor camostat mesilate provides further renoprotection in a rat chronic kidney disease model.
Narita, Y., Ueda, M., Uchimura, K., Kakizoe, Y., Miyasato, Y., Mizumoto, T., Morinaga, J., Hayata, M., Nakagawa, T., Adachi, M., Miyoshi, T., Sakai, Y., Kadowaki, D., Hirata, S., Mukoyama, M., and Kitamura, K.
J Pharmacol Sci., 130: 110-116, 2016
Angiopoietin-like protein 2 increases renal fibrosis by accelerating transforming growth factor-β signaling in chronic kidney disease.
Morinaga, J., Kadomatsu, T., Miyata, K., Endo, M., Terada, K., Tian, Z., Sugizaki, T., Tanigawa, H., Zhao, J., Zhu, S., Sato, M., Araki, K., Iyama, K., Tomita, K., Mukoyama, M., Tomita, K., Kitamura, K., and Oike, Y.
Kidney Int., 89: 327-341, 2016
Successful treatment of rapidly progressive Immunoglobulin A nephropathy with human immunodeficiency virus infection by steroid pulse therapy and tonsillectomy.Miyasato, Y., Miyoshi, T., Fujimoto, D., Adachi, M., Kitamura, K., and Mukoyama, M.
Nephrology, 21: 159-160, 2016
Elevated levels of autoantibodies against ATP2B4 and BMP-1 in sera of patients with atherosclerosis-related diseases
Hiwasa, T., Machida, T., Zhang, X.M., Kimura, R., Wang, H., Iwase, K., Ashino, H., Taira, A., Arita, E., Mine, S., Ohno, M., Chen, P.M., Nishi, E., Kitamura, K., Yamazoe, R., Takizawa, H., Kashiwado, K., Kamitsukasa, I., Wada, T., Aotsuka, A., Kobayashi, E., Matsutani, T., Iwadate, Y., Saeki, N., Mori, M., Uzawa, A., Muto, M., Sugimoto, K., Kuwabara, S., Iwata, Y., Nakayama, T., Harada, J., Kobayashi, Y., Takemoto, M., Kobayashi, K., Kawamura, H., Ishibashi, R., Sakurai, K., Fujimoto, M., Yokote, K., Goto, K., Matsumura, R., Sugiyama, T., Hayashi, H., Hasegawa, R., Shimada, H., Ito, M., Kudo, T., Doi, H., Nakamura, R., Tomiyoshi, G., Shinmen, N., and Kuroda, H.
Immunome Res., 11: 097, 2015
Low-density lipoprotein apheresis for proteinuria in lupus nephritis with intraglomerular foam cells containing cholesterol crystals
Shiraishi, N., Kitamura, K., Hayata, M., Ogata, T., Tajiri-Okamura, K., Nakayama, Y., Kohda, Y., Tomita, K., and Mukoyama, M.
Am. J. Kidney Dis., 65: 490-493, 2015
The Serine Protease Inhibitor Camostat Mesilate Attenuates the Progression of Chronic Kidney Disease through its Antioxidant Effects Ueda, M., Uchimura, K., Narita, Y., Miyasato, Y., Mizumoto, T., Morinaga, J., Hayata, M., Kakizoe, Y., Adachi, M., Miyoshi, T., Shiraishi,
N., Kadowaki, D., Sakai, Y., Mukoyama, M., and Kitamura, K.
Nephron Exp. Nephrol., 129: 223-232, 2015
Association of serum antibody levels against TUBB2C with diabetes and cerebral infarction.
Hiwasa, T., Zhang, X.M., Kimura, R., Machida, T., Kitamura, K., Yamazoe, R., Kunimatsu, M., Mine, S., Kobayashi, E., Iwadate, Y., Saeki, N., Takemoto, M., Kobayashi, K., Kawamura, H., Ishibashi, R., Sakurai, K., Fujimoto, M., Yokote, K., Iwata, Y., Nakayama, T., Harada, J., Kobayashi, Y., Ohno, M., Chen, P.M., Nishi, E., Yokota, M., Kamitsukasa, I., Wada, T., Aotsuka, A., Mori, M., Uzawa, A., Muto, M., Sugimoto, K., Kuwabara, S., Goto, K., Matsumura, R., Sugiyama, T., Takizawa, H., Shimada, H., Ito, M., Wang, H., Taira, A., Arita, E., Iwase, K., Kudo, T., Doi, H., Nakamura, R., Tomiyoshi, G., Shinmen, N., and Kuroda, H.
Gratis J. Biomed. Sci., 1: 49-63, 2015
A Possible Reno-protective Effect of Systemic Thermal Stimulation in a Mouse Remnant Kidney Model
Iwashita, Y., Yoza, Y., Kameyama, H., Mukoyama, M., Iiyama, J., and Kitamura, K.
J. Jpn. Soc. Balneol. Climatol. Phys. Med., 78: 118-19, 2015
助成金
内村 幸平：日本学術振興会 若手B
内村 幸平：中冨健康科学振興財団
内村 幸平：ノバルティス科学振興財団
内村 幸平：持田記念医学薬学振興財団
内村 幸平：ASN Kidney Week and the Kidney STARS program Travel Grant,
2014年
英文原著論文
Yoshizawa T, Karim MF, Sato Y, Senokuchi T, Miyata K, Fukuda T, Go C, Tasaki M, Uchimura K, Kadomatsu T, Tian Z, Smolka C, Sawa T, Takeya M, Tomizawa K, Ando Y, Araki E, Akaike T, Braun T, Oike Y, Bober E, Yamagata K. : SIRT7 controls hepatic lipid metabolism by regulating the ubiquitin-proteasome pathway. Cell Metab 19 : 712-721, 2014
Shiraishi, N., Kitamura, K., Hayata, M., Ogata, T., Tajiri-Okamura, K., Nakayama, Y., Kohda, Y., Tomita, K., and Mukoyama, M. : Low-density lipoprotein apheresis for proteinuria in lupus nephritis with intraglomerular foam cells containing cholesterol crystals. Am. J. Kidney Dis., in press, 2014
Kuragano, T., Matsumura, O., Matsuda, A., Hara, T., Kiyomoto, H., Murata, T., Kitamura, K., Fujimoto, S., Hase, H., Joki, N., Fukatsu, A., Inoue, T., Itakura, I., and Nakanishi, T. : Association between hemoglobin variability, serum ferritin levels and mortality in maintenance hemodialysis patients. Kidney Int., 86: 845-854, 2014
Shiraishi,N., Kitamura, K., Kohda, Y., Iseki, K., and Tomita, K. : Prevalence and risk factor analysis of nephrosclerosis and ischemic nephropathy in the Japanese general population. Clin. Exp. Nephrol., 18: 461-468, 2014
Uchimura, K., Hayata, M., Mizumoto, T., Miyasato, Y., Kakizoe, Y., Morinaga, J., Onoue, T., Yamazoe, R., Ueda, M., Adachi, M., Miyoshi, T., Shiraishi, N., Ogawa, W., Fukuda, K., Kondo, T., Matsumura, T., Araki, E., Tomita, K., and Kitamura, K. : The serine protease prostasin regulates hepatic insulin sensitivity by modulating TLR4 signaling. Nat. Commun., 5: 3428, 2014
Ichijo S, Furuya F, Shimura H, Hayashi Y, Takahashi K, Ohta K, Kobayashi T, Kitamura K : Activation of the RhoB Signaling Pathway by Thyroid Hormone Receptor β in Thyroid Cancer Cells. PLoS ONE 9 : e116252, 2014
Furuya F, Shimura H, Yokomichi H, Takahashi K, Akiyama D, Asakawa C, Okamura A, Motosugi A, Haraguchi K, Yamagata Z, Kobayashi T : Neutrophil gelatinase-associated lipocalin levels associated with cardiovascular disease in chronic kidney disease patients. Clin Exp Nephrol 18 : 778-783, 2014
Takahashi K, Furuya F, Shimura H, Kaneshige M, Kobayashi T : Impaired oxidative endoplasmic reticulum stress response caused by deficiency of thyroid hormone receptor α. J Biol Chem 289 : 12485-12493, 2014
Furuya F, Shimura H, Takahashi K, Akiyama D, Motosugi A, Ikegishi Y, Haraguchi K, Kobayashi T : Skin autofluorescence is a predictor of cardiovascular disease in chronic kidney disease patients. Ther Apher Dial 19 : 40-44, 2014
受賞
古屋文彦：日本甲状腺学会 七條賞
2013年
英文原著論文
Morinaga, J., Kakizoe, Y., Miyoshi, T., Onoue, T., Ueda, M., Mizumoto, T., Yamazoe, R., Uchimura, K., Hayata, M., Shiraishi, N., Adachi, M., Sakai, Y., Tomita, K., and Kitamura, K. : The antifibrotic effect of a serine protease inhibitor in the kidney. Am. J. Physiol. (Renal Physiol.), 305: F173-181, 2013
Olivieri, O., Chiecchi, L., Pizzolo, F., Castagna, A., Raffaelli, R., Gunasekaran, M., Guarini, P., Consoli, L., Salvagno, G., and Kitamura, K. : Urinary prostasin in normotensive individuals: correlation with the aldosterone to renin ratio and urinary sodium. Hypertens. Res., 36: 528-533, 2013
Wakui, H., Tamura, K., Masuda, S., Tsurumi-Ikeya, Y., Fujita, M., Maeda, A., Ohsawa, M., Azushima, K., Uneda, K., Matsuda, M., Kitamura, K., Uchida, S., Toya, Y., Kobori, H., Nagahama, K., Yamashita, A., and Umemura, S. : Enhanced angiotensin receptor-associated protein in renal tubule suppresses angiotensin-dependent hypertension. Hypertension, 61: 1203-1210, 2013
Ushio-Yamana, H., Minegishi, S., Ishigami, T., Araki, N., Umemura, M., Tamura, K., Maeda, E., Kakizoe, Y., Kitamura, K., and Umemura, S. : Renin angiotensin antagonists normalize aberrant activation of epithelial sodium channels in sodium-sensitive hypertension. Nephron Exp. Nephrol., 122: 95-102, 2013
2012年
英文原著論文
Kadowaki, D., Sumikawa, S., Arimizu, K., Taguchi, K., Kitamura, K., Ishitsuka, Y., Narita, Y., Irie, T., Chuang, V.T., Maruyama, T., Otagiri, M., and Hirata, S. : Effect of acetaminophen on the progression of renal damage in adenine induced renal failure model rats. Life Sci., 91: 1304-1308, 2012
Hayata, M., Kakizoe, Y., Uchimura, K., Morinaga, J., Yamazoe, R., Mizumoto, T., Onoue, T., Ueda, M., Shiraishi, N., Adachi, M., Miyoshi, T., Sakai, Y., Tomita, K., and Kitamura, K. : Effect of a serine protease inhibitor on the progression of chronic renal failure. Am. J. Physiol. (Renal Physiol.), 303: F1126-1135, 2012
Uchimura, K., Kakizoe, Y., Onoue, T., Hayata, M., Morinaga, J., Yamazoe, R., Ueda, M., Mizumoto, T., Adachi, M., Miyoshi, T., Shiraishi, N., Sakai, Y., Tomita, K., and Kitamura, K. : In vivo contribution of serine proteases to the proteolytic activation of γENaC in aldosterone-infused rats. Am. J. Physiol. (Renal Physiol.), 303: F939-943, 2012
Shiraishi, N., Kitamura, K., Hayata, M., Ogata, T., Adachi, M., Kajiwara, K., Ikeda, H., Miyoshi, T., and Tomita, K. : Case of anti-glomerular basement membrane antibody-induced glomerulonephritis with cytomegalovirus-induced thrombotic microangiopathy. Intern. Med. J., 42: e7-11, 2012
Kitamura, K. and Tomita, K. : Proteolytic activation of the epithelial sodium channel and therapeutic application of a serine protease inhibitor for the treatment of salt-sensitive hypertension. Clin. Exp. Nephrol., 16: 44-48, 2012
2011年
英文原著論文
Tasic, V., Hynes, A.M., Kitamura, K., Cheong, H.I., Lozanovski, V.J., Gucev, Z., Jutabha, P., Anzai, N., and Sayer, J.A. : Clinical and functional characterization of URAT1 variants. PLoS One, 6: e28641, 2011
Adachi, M., Miyoshi, T., Shiraishi, N., Shimada, H., Sakaguchi, S., Tomita, K., and Kitamura, K. : A study of maintenance therapy after intravenous maxacalcitol for secondary hyperparathyroidism. Clin. Nephrol., 76: 266-272, 2011
Anraku, M., Takeuchi, K., Watanabe, H., Kadowaki, D., Kitamura, K., Tomita, K., Kuniyasu, A., Suenaga, A., Maruyama, T., and Otagiri, M. : Quantitative analysis of cysteine-34 on the anitioxidative properties of human serum albumin in hemodialysis patients. J. Pharm. Sci., 100: 3968-3976, 2011
2010年
英文原著論文
Ko, T., Kakizoe, Y., Wakida, N., Hayata, M., Uchimura, K., Shiraishi, N., Miyoshi, T., Adachi, M., Aritomi, S., Konda, T., Tomita, K., and Kitamura, K. : Regulation of adrenal aldosterone production by serine protease prostasin. J. Biomed. Biotechnol., 2010: 793843, 2010
Jutabha, P., Anzai, N., Kitamura, K., Taniguchi, A., Kaneko, S., Yan, K., Yamada, H., Shimada, H., Kimura, T., Katada, T., Fukutomi, T., Tomita, K., Urano, W., Yamanaka. H., Seki, G., Fujita, T., Moriyama, Y., Yamada, A., Uchida, S., Wempe, M. F., Endou, H., and Sakurai, H. : Human sodiumphosphate transporter 4 (hNPT4/SLC17A3) as a common renal secretory pathway for drugs and urate. J. Biol. Chem., 285: 35123-35132, 2010
Kitamura, K. and Tomita, K. : Regulation of renal sodium handling through the interaction between serine proteases and serine protease inhibitors. Clin. Exp. Nephrol., 14: 405-410, 2010
Chai, K., Kitamura, K., McCann, A., and Wu, X.R. : The epithelium-molecular landscaping for an interactive barrier. J. Biomed. Biotechnol., 2010: 870506, 2010
Sugahara, T., Koga, T., Ueno-Shuto, K., Shuto, T., Watanabe, E., Maekawa, A., Kitamura, K., Tomita, K., Mizuno, A., Sato, T., Suico, M. A., and Kai, H. : Calreticulin positively regulates the expression and function of epithelial sodium channel. Exp. Cell Res., 315: 3294-3300, 2009
Kakizoe, Y., Kitamura, K., Ko, T., Wakida, N., Maekawa, A., Miyoshi, T., Shiraishi, N., Adachi, M., Zhang, Z., Masilamani, S., and Tomita, K. : Aberrant ENaC activation in Dahl salt-sensitive rats. J. Hypertens., 27: 1679-1689, 2009
Maekawa, A., Kakizoe, Y., Miyoshi, T., Wakida, N., Ko, T., Shiraishi, N., Adachi, M., Tomita, K., and Kitamura, K. : Camostat mesilate inhibits prostasin activity and reduces blood pressure and renal injury in salt-sensitive hypertension. J. Hypertens., 27: 181-189, 2009
Koda, A., Wakida, N., Toriyama, K., Yamamoto, K., Iijima, H., Tomita, K., and Kitamura, K. : Urinary prostasin in humans: relationships among prostasin, aldosterone and epithelial sodium channel activity. Hypertens. Res., 32: 276-281, 2009
Nonoguchi, H., Kohda, Y., Fukutomi, R., Nakayama, Y., Naruse, M., Kitamura, K., Inoue, T., Nakanishi, T., and Tomita, K. : A case with acute renal failure and subsequent nephrotic syndrome. Ren. Fail., 31: 162-166, 2009
Haraguchi K, Hara S, Ubara Y, Tanaka S, Nukui I, Shimura H, Ohashi K, Kobayashi T : Complete remission of diabetic nephropathy in a type 1 diabetic patient with near-nephrotic range proteinuria and reduced renal function. Diabetes Res Clin Pract 83 : 295-299, 2009
2008年
英文原著論文
Anraku, M., Kitamura, K. (equal contribution), Shintomo, R., Takeuchi, K., Ikeda, H., Nagano, J., Ko, T., Mera, K., Tomita, K., and Otagiri, M. : Effect of intravenous iron administration frequency on AOPP and inflammatory biomarkers in chronic hemodialysis patients: a pilot study. Clin. Biochem., 41: 1168-1174, 2008
Anzai, N., Ichida, K., Jutabha, P., Kimura, T., Babu, E., Jin, C.J., Srivastava, S., Kitamura, K., Hisatome, I., Endou, H., and Sakurai, H. : Plasma urate level is directly regulated by a voltage-driven urate efflux transporter URATv1 (SLC2A9) in humans. J. Biol. Chem., 283: 26834-26838, 2008
Iwao, Y., Nakajou, K., Nagai, R., Kitamura, K., Anraku, M., Maruyama, T., and Otagiri, M. : CD36 is one of important receptors promoting renal tubular injury by advanced oxidation protein products. Am. J. Physiol. (Renal Physiol.), 295: F1871-F1880, 2008
Nonoguchi, H., Kiyama, S., Kitamura, K., Naruse, M., Tomita, M., Tazoe, N., Tajiri, M., Nakayama, Y., Kohda, Y., Inoue, T., and Tomita, K. : Long-term plasma levels and dose modulation of alacepril in patients with chronic renal failure. Hypertens Res., 31: 29-36, 2008
2007年
英文原著論文
Shimoishi, K., Anraku, M., Kitamura, K., Tasaki, Y., Taguchi, K., Hashimoto, M., Fukunaga, E., Maruyama, T., and Otagiri, M. : An oral adsorbent, AST-120 protects against the progression of oxidative stress by reducing the accumulation of indoxyl sulfate in the systemic circulation in renal failure. Pharm. Res., 24: 1283-1289, 2007
Kadowaki, D., Anraku, M., Tasaki, Y., Kitamura, K., Wakamatsu, S., Tomita, K., Gebicki, J. M., Maruyama, T., and Otagiri, M. : Effect of olmesartan on oxidative stress in hemodialysis patients. Hypertens. Res., 30: 395-402, 2007
2006年
英文原著論文
Wakida, N., Kitamura, K., Tuyen, D.G., Maekawa, A., Miyoshi, T., Adachi, M., Shiraishi, N., Ko, T., Ha, V., Nonoguchi, H., and Tomita, K. : Inhibition of prostasin-induced ENaC activities by PN-1 and regulation of PN-1 expression by TGF-β1 and aldosterone. Kidney Int., 70: 1432-1438, 2006
Shiraishi, N., Kitamura, K., Miyoshi, T., Adachi, M., Kohda, Y., Nonoguchi, H., Misumi, S., Maekawa, Y., Murayama, T., Tomita, M., and Tomita, K. : Successful treatment of a patient with severe calcific uremic arteriolopathy (calciphylaxis) by etidronate disodium . Am. J. Kidney Dis., 48: 151-154, 2006
Haraguchi K, Kubo M, Saito T, Furuya F, Inoue H, Takahashi M, Shimura H, Tago K, Kobayashi T : Serum level of macrophage colony-stimulating factor and atherosclerosis in hemodialysis patients. Nephron Clin Pract 102 : c14-20, 2006
2005年
英文原著論文
Nagano, J., Kitamura, K., Hujer, K.M., Ward, C.J., Bram, R.J., Hopfer, U., Tomita, K., Huang, C., and Miller, R.T. : Fibrocystin Interacts with CAML, a protein involved in Ca2+ signaling. Biochem. Biophys. Res. Commun., 338: 880-889, 2005
Shimada, H., Kitamura, K. (equal contribution), Anraku, M., Miyoshi, T., Adachi, M., Tuyen, D.G., Wakamatsu, S., Nonoguchi, H., Tanaka, M., and Tomita, K. : Effect of telmisartan on ambulatory blood pressure monitoring, plasma brain natriuretic peptide, and oxidative status of serum albumin in hemodialysis patients. Hypertens. Res., 28: 987-994, 2005
Mera, K., Anraku, M., Kitamura, K., Nakajou, K., Maruyama, T., Tomita, K., and Otagiri, M. : Oxidation and carboxyl methyl lysine-modification of albumin: possible involvement in the progression of oxidative stress in hemodialysis patients. Hypertens. Res., 28: 973-980, 2005
Mera, K., Anraku, M., Kitamura, K., Nakajou, K., Maruyama, T., and Otagiri, M. : The structure and function of oxidized albumin in hemodialysis patients: Its role in elevated oxidative stress via neutrophil burst. Biochem. Biophys. Res. Commun., 334: 1322-1328, 2005
Wakida, N., Tuyen, D.G., Adachi, M., Miyoshi, T., Nonoguchi, H., Oka, T., Ueda, O., Tazawa, M., Kurihara, S., Yoneta, Y., Shimada, H., Oda, T., Kikuchi, Y., Matsuo, H., Hosoyamada, M., Endou, H., Otagiri, M., Tomita, K., and Kitamura, K. : Mutations in human urate transporter 1 gene in presecretory reabsorption defect type of familial renal hypouricemia. J. Clin. Endocrinol. Metab., 90: 2169-2174, 2005
Furuhashi, M., Kitamura, K., Adachi, M., Miyoshi, T., Wakida, N., Ura, N., Shikano, Y., Shinshi, Y., Sakamoto, K., Hayashi, M., Satoh, N., Nishitani, T., Tomita, K., Shimamoto, K. : Liddle’s syndrome caused by a novel mutation in the proline-rich PY motif of the epithelial sodium channel β-subunit. J. Clin. Endocrinol. Metab., 90: 340-344, 2005
Tuyen, D.G., Kitamura, K., Adachi, M., Miyoshi, T., Wakida, N., Nagano, J., Nonoguchi, H., and Tomita, K. : Inhibition of prostasin expression by TGF-β1 in renal epithelial cells. Kidney Int., 67: 193-200, 2005
Kitamura, K. and Tomita, K. : Familial pseudohyperkalemia: a rare syndrome, but diverse genetic heterogeneity. Intern Med., 44: 781-782, 2005
2004年
英文原著論文
Anraku, M., Kitamura, K. (equal contribution), Shinohara, A., Adachi, M., Suenaga, A., Maruyama, T., Miyanaka, K., Miyoshi, T., Shiraishi, N., Nonoguchi, H., Otagiri, M., and Tomita, K. : Intravenous iron administration induces oxidation of serum albumin in hemodialysis patients. Kidney Int., 66: 841-848, 2004
2003年
英文原著論文
Okumura, Y., Nishikawa, M., Cui, P., Shiota, M., Nakamura, Y., Adachi, M., Kitamura, K., Tomita, K., and Kido, H. : Cloning and characterization of a transmembrane-type serine protease from rat kidney, a new sodium channel activator. Biol. Chem., 384: 1483-1495, 2003
Iwashita, K., Kitamura, K., Narikiyo, T., Adachi, M., Shiraishi, N., Miyoshi, T., Nagano, J., Tuyen, D.G., Nonoguchi, H., and Tomita, K. : Inhibition of prostasin secretion by serine protease inhibitors in the kidney. J. Am. Soc. Nephrol., 14: 11-16, 2003
Shiraishi, N., Kitamura, K., Kohda, Y., Narikiyo, T., Adachi, M., Miyoshi, T., Iwashita, K., Nonoguchi, H., Miller, R.T., and Tomita, K. : Increased endothelin-1 expression in the kidney in hypercalcemic rats. Kidney Int., 63: 845-852, 2003
Nonoguchi, H., Kiyama, S., Inoue, H., Nakayama, Y., Inoue, T., Kohda, Y., Machida, K., Tajima, A., Kitamura, K., Miyoshi, T., Shimada, H., Shimada, H., Tajiri, M., Honda, Y., Tanaka, M., and Tomita, K. : Angiotensin-converting enzyme inhibitor withdrawal and ACE gene polymorphism. Clin. Nephrol., 60: 225-232, 2003
Tanaka, M., Itoh, K., Matsushita, K., Matsushita, K., Wakita, N., Adachi, M., Nonoguchi, H., Kitamura, K., Hosoyamada, M., Endou, H., and Tomita, K. : Two male siblings with hereditary renal hypouricemia and exercise-induced ARF. Am. J. Kidney Dis., 42:1287-1292, 2003
2002年
英文原著論文
Narikiyo, T., Kitamura, K., Adachi, M., Miyoshi, T., Iwashita, K., Shiraishi, N., Nonoguchi, H., Chen, L.M., Chai, K.X., Chao, J., and Tomita, K. : Regulation of prostasin by aldosterone in the kidney. J. Clin. Invest., 109: 401-408, 2002
Yamakawa, K., Kitamura, K., Nonoguchi, H., Takasu, N., Miller, R.T., and Tomita, K. : Gα13 induces preproET-1 gene expression via JNK. Hypertens. Res., 25: 427-432, 2002
Kitamura, K. and Tomita, K. : Endothelin receptor antagonists prevent parathyroid cell proliferation caused by hypocalcemia in rats. Curr. Opin. Nephrol. Hypertens., 11: 411-415, 2002
2001年
英文原著論文
Adachi, M., Kitamura, K., Miyoshi, T., Narikiyo, T., Iwashita, K., Shiraishi, N., Nonoguchi, H., and Tomita, K. : Activation of epithelial sodium channels by prostasin in Xenopus oocytes. J. Am. Soc. Nephrol. 12: 1114-1121, 2001
Kyuma, M., Ura, N., Torii, T., Takeuchi, H., Takizawa, H., Kitamura, K., Tomita, K., Sasaki, S., and Shimamoto, K. : A family with Lliddle’s syndrome caused by a mutation in the β subunit of the epithelial sodium channel. Clin. Exp. Hypertens. 23: 471-478, 2001
1999年
英文原著論文
Kitamura, K., Shiraishi, N., Singer, W.D., Handlogten, M.E., Tomita, K., and Miller, R.T. : Endothelin-B receptors activate Gα13. Am. J. Physiol. (Cell Physiol.), 276: C930-C937, 1999
1997年
英文原著論文
Kitamura, K., Tomita, K., and Miller, R.T. : Inhibition of nitric oxide synthase activity and nitric oxide-dependent calcium influx in renal epithelial cells by cyclic adenosine monophosphate: Implications for cell injury. J. Am. Soc. Nephrol. 8: 558-568, 1997
1996年
英文原著論文
Kitamura, K., Singer, W.D., Star, R.A., Muallem, S., and Miller, R.T. : Induction of inducible nitric-oxide synthase by the heterotrimeric G protein Gα13. J. Biol. Chem. 271: 7412-7415, 1996
Khair-El-Din, T., Sicher, S.C., Vazquez, M.A., Chung, G.W., Stallworth, K.A., Kitamura, K., Miller, R.T., and Lu, C.Y. : Transcription of the murine iNOS gene is inhibited by docosahexaenoic acid, a major constituent of fetal and neonatal sera as well as fish oils. J. Exp. Med. 183: 1241-1246, 1996
1995年
英文原著論文
Xu, X., Kitamura, K. (equal contribution), Lau, K.S., Muallem, S., and Miller, R.T. : Differential regulation of Ca2+ release-activated Ca2+ influx by heterotrimeric G proteions. J. Biol. Chem. 270: 29169-29175, 1995
Kugi, M., Kitamura, K., Cottam, G.L., and Miller, R.T. : Expression of Gαi2 mimics several aspects of LPS priming in a murine macrophage-like cell line. J. Inflamm. 45: 175-182, 1995
Kitamura, K., Singer, W.D., Cano, A., and Miller, R.T. : Gαq and Gα13 regulate NHE-1 and intracellular calcium in epithelial cells. Am. J. Physiol. (Cell Physiol.), 268: C101-C110, 1995
1994年
英文原著論文
Kitamura, K. and Miller, R.T. : Regulation of hormone-sensitive calcium influx by the adenylyl cyclase system in renal epithelial cells. J. Clin. Invest. 94: 328-336, 1994
